Windows Vista and Windows 7 have an option to encrypt the page file.
http://www.technipages.com/vista-encrypt-the-pagefile.htmlfsutil behavior set encryptpagingfile 1
fsutil behavior set encryptpagingfile 0
Requires administrator privileges. PC has to be rebooted to apply the changes.
Everytime the PC starts up, it generates a random key to encrypt the page file with. When the PC is shutdown, the key is lost and all the information in the page file is lost with it.
This method is safer than wiping the page file. If your PC loses power for example, the page file never gets wiped and all the information is still there on the hard drive. But if the page file is encrypted, the key is stored in memory and is lost if the PC loses power, so the page file cannot be decrypted.
The page file can be used to leak important information. For example, several programs may store passwords in RAM in an easily readable format. If this part of RAM gets knocked to the page file, the password will remain unencrypted on the hard drive until it's overwritten by something else.
The encryption does require some processing power, so this may make your PC run slower.